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Human proteome project
The Human Proteome Project〔Legrain, P. et al. The human proteome project: Current state and future direction. Mol Cell Proteomics. 10:M111.009993 (2011).〕 (HPP) is a collaborative effort coordinated by the Human Proteome Organization.〔HUPO (Human Proteome Organization) 1st World Congress. Mol Cell Proteomics. 9:651-752 (2002).〕 Its stated goal is to experimentally observe all of the proteins produced by the sequences translated from the human genome.
==History==
The Human Proteome Organization has served as a coordinating body for many long-running proteomics research projects associated with specific human tissues of clinical interest, such as blood plasma,〔Omenn, G.S. et al. Overview of the HUPO Plasma Proteome Project. ''Proteomics''. 5, 3226-45 (2005).〕 liver,〔He, F. Human liver proteome project: plan, progress, and perspectives. Mol Cell Proteomics. 4, 1841-8 (2005).〕 brain 〔Hamacher, M. et al. HUPO Brain Proteome Project: toward a code of conduct. Mol Cell Proteomics. 7, 457 (2008).〕 and urine.〔Yamamoto, T., Langham, R.G., Ronco, P., Knepper, M.A. & Thongboonkerd, V. Towards standard protocols and guidelines for urine proteomics. ''Proteomics''. 8, 2156-9 (2008).〕 It has also been responsible for projects associated with specific technology 〔Uhlen, M. & Ponten, F. Antibody-based proteomics for human tissue profiling. Mol Cell Proteomics. 4, 384-93 (2005).〕 and standards 〔Orchard, S. et al. Current status of proteomic standards development. Expert Rev Proteomics. 1, 179-83 (2005).〕 necessary for the large scale study of proteins.
The structure and goals of a larger project that would parallel the Human Genome Project has debated in the scientific literature.〔Archakov A, et al. The Moscow HUPO Human Proteome Project workshop.
Mol Cell Proteomics. 8:2199-200 (2009).〕〔Baker MS. Building the 'practical' human proteome project - the next big thing in basic and clinical proteomics. Curr Opin Mol Ther. 2009 11:600-2 (2009).〕〔Editorial, The call of the human proteome. Nat Methods. 7:661 (2010).〕〔Rabilloud T., et al. Is a gene-centric human proteome project the best way for proteomics to serve biology? ''Proteomics''. 10:3067-72 (2010).〕〔Editorial. A Gene-centric Human Proteome Project. Mol Cell Proteomics. 9:427-429 (2010).〕 The results of this debate and a series of meetings at the World Congresses of the Human Proteome Organization in 2009, 2010 and 2011 has been the decision to define the Human Proteome Project as being composed of two sub-projects, C-HPP and B/D-HPP.〔Paik, Y-K., et al. A Chromosome-Centric Human Proteome Project to Characterize the Sets of Proteins Encoded in the Genome. Nature Biotech.30: 221–3(2012).〕 The C-HPP will be organized into 25 groups, one per human chromosome. The B/D-HPP will be organized into groups by the biological and disease relevance of proteins.〔Aebersold R., et al. The Biology/Disease-driven Human Proteome Project (B/D-HPP): Enabling Protein Research for the Life Sciences Community. ''J. Proteome Res''. 12:23–27 (2013).〕
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